First Legs February 15 & 16 and 22 & 23 | Second Legs March 8 & 9 and 15 & 16 |
| AS Roma | v | Shakhtar Donetsk |
| AC Milan | v | Tottenham Hotspur |
| Valencia | v | FC Schalke |
| Inter Milan | v | Bayern Munich |
| Lyon | v | Real Madrid |
| Arsenal | v | Barcelona |
| Marseille | v | Manchester United |
| Copenhagen | v | Chelsea |
